The key difference between Celecoxib and Ibuprofen is that Celecoxib is a selective COX-2 inhibitor and does no longer reason gastrointestinal ulcers, whilst Ibuprofen is a non-selective COX-1 and COX-2 inhibitor and thereby causes gastrointestinal ulcers.
The key difference between Celecoxib and Ibuprofen is that Celecoxib is a selective COX-2 inhibitor and does no longer reason gastrointestinal ulcers, whilst Ibuprofen is a non-selective COX-1 and COX-2 inhibitor and thereby causes gastrointestinal ulcers.
What is Celecoxib?
Celecoxib is a nonsteroidal anti inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2 (COX-2) while treating grownup osteoarthritis (OA) and rheumatoid arthritis (RA). It may be combined with tramadol whilst handling acute ache in adults. Unlike different NSAIDs, it does now not increase the danger of gastrointestinal bleeding and, consequently, changed into granted FDA approval in 1998. Celecoxib has additionally been evaluated for its powerful anticancer activities in scientific trials in opposition to diverse cancers. Interestingly, Celecoxib selectively inhibits handiest COX-2, that’s closely expressed in inflamed tissues. The inhibition of COX-2 reduces the synthesis of prostaglandin E2 (PGE2), prostacyclin (PGI2), thromboxane (TXA2), prostaglandin D2 (PGD2), and prostaglandin F2 (PGF2), which reason ache.
What is Ibuprofen?
Celecoxib and ibuprofen are both nonsteroidal anti-inflammatory drugs (NSAIDs), however they’ve a few critical variations. Celecoxib is a selective COX-2 inhibitor, suggesting it by and large inhibits the COX-2 enzyme. In comparison, Ibuprofen is a nonselective NSAID inhibiting COX-1 and COX-2 enzymes. Celecoxib is much less in all likelihood to motive gastrointestinal side consequences, including belly bleeding and ulcers. In evaluation, Ibuprofen is much more likely to motive gastrointestinal aspect effects than celecoxib. Celecoxib has an extended half of-existence than ibuprofen, suggesting that it wishes to be taken less regularly. Furthermore, ibuprofen is extra powerful at decreasing fever than celecoxib.
What is the Difference Between Celecoxib and Ibuprofen?
Celecoxib and ibuprofen are both nonsteroidal anti inflammatory tablets (NSAIDs), however they’ve some critical differences. Celecoxib is a selective COX-2 inhibitor, suggesting it typically inhibits the COX-2 enzyme. In contrast, Ibuprofen is a nonselective NSAID inhibiting COX-1 and COX-2 enzymes. Celecoxib is much less probable to motive gastrointestinal aspect results, which includes belly bleeding and ulcers. In assessment, Ibuprofen is more likely to motive gastrointestinal facet effects than celecoxib. Celecoxib has a longer half of-lifestyles than ibuprofen, suggesting that it needs to be taken less often. Furthermore, ibuprofen is more powerful at lowering fever than celecoxib.
Summary – Celecoxib vs. Ibuprofen
1. Gong, Li, et al. “Celecoxib pathways.” Pharmacogenetics and Genomics, vol. 22, no. Four, 2012, pp. 310–318._x000D_
2. Rainsford, okay. D. “Ibuprofen: Pharmacology, efficacy and protection.” Inflammopharmacology, vol. 17, no. 6, 2009, pp. 275–342.
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